Cortical spreading depression in migraine-time to reconsider?
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چکیده
منابع مشابه
Cortical spreading depression in migraine-time to reconsider?
New evidence concerning the pathophysiology of migraine has come from the results of therapeutic transcranial magnetic stimulation (tTMS). The instantaneous responses to single pulses applied during the aura or headache phase, together with a number of other observations, make it unlikely that cortical spreading depression is involved in migraine. tTMS is considered to act by abolishing abnorma...
متن کاملP141: The Role of Microglia in Cortical Spreading Depression in Migraine
Migraine is a disorder that afflicts nearly one tenth of the population. Involving both nervous and vascular system, it has been found as a prominent factor of disability. The migraine attacks may be initiated in the brainstem or may begin peripherally in the meninges while the role of cortical activation preceding an attack is also debated. Although available treatments, more studies on migrai...
متن کاملAre cortical spreading depression and headache in migraine causally linked?
During the past few decades, much controversy has surrounded the pathophysiology of migraine. Cortical spreading depression (CSD) is widely accepted as the neuronal process underlying visual auras. It has been proposed that CSD can also cause the headaches, at least in migraine with aura. We describe three patients, each fulfilling the International Headache Society criteria for migraine with a...
متن کامل[Cortical spreading depression and molecular genetics in migraine].
Cortical spreading depression (CSD) is a slowly propagated wave of depolarization of neurons and glial cells, followed by a subsequent sustained suppression of spontaneous neuronal activity. Functional imaging studies of migraine patients have shown dramatic changes in blood flow and brain activity whose characteristics are similar to those of CSD, implicated in migraine visual aura. Although t...
متن کاملP 23: Apoptosis Following Cortical Spreading Depression in Juvenile Rats
Introduction: Repetitive cortical spreading depression (CSD) can lead to cell death in immature brain tissue. Caspases are involved in neuronal cell death in several CSD-related neurological disorders. Yet, whether repetitive CSD itself can induce caspase activation in adult or juvenile tissue remains unknown. Inducing repetitive CSD in somatosensory cortices of juvenile and adult rats in vivo,...
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ژورنال
عنوان ژورنال: Arquivos de Neuro-Psiquiatria
سال: 2015
ISSN: 0004-282X
DOI: 10.1590/0004-282x20150094